Anavar is the trade name for an oral anabolic steroid with the chemical name Oxandrolone. The appearance of the drug occurred during the period of active research into anabolic steroids, which lasted from the 1950s to the 1980s. The aim of the research was to develop an anabolic compound that could be considered ideal. And the creators of Anavar, perhaps, managed to get as close as possible to this goal. The drug has an excellent safety profile and the ratio of the risk of side effects to the expected benefit. This is one of the few steroids that can be prescribed for the treatment of children and women. In these two groups of patients, anabolic steroids are used extremely rarely due to the risk of adverse reactions.
For the first time, the drug Oxandrolone became known in 1962. A little later, it was introduced by Searle Laboratories (Pfizer Inc) under the brand name Anavar. Subsequently, various pharmaceutical companies have released Oxandrolone under other trade names. Among them: Protivar, Anatrophil, Antitriol, Lipidex and Lonavar. The drug has become one of the significant achievements of the pharmaceutical industry, which is confirmed by numerous data on the good tolerance of Anavar by the majority of patients.
Anavar is a dihydrotestosterone derivative whose structure has been modified to give new properties to the compound. The first of the changes is C17-alpha alkylation, which makes it possible to take the drug orally. The second is the replacement of carbon in the 2nd position with oxygen, which enhanced the anabolic properties of the compound. The anabolic efficiency of Anavar is 3-6 times higher than that of Testosterone.
Anavar belongs to the dihydrotestosterone family along with other agents such as Masteron, Primobolan, Winstrol, and others. The common feature of these drugs is that they are all derived from DHT. Therefore, DHT is considered to be the “main” hormone of all compounds in the family. Anavar has a significant predominance of anabolic versus androgenic effects (as evidenced by comparing the anabolic index (322-630) with androgenic effects (24)). The testosterone index ratio is 100: 100. It is clear that oxandrolone has much less androgenic effects and a much more pronounced anabolic effect than testosterone. The anabolic activity of Anavar may be 3 to 6 times higher than the similar effects of testosterone, whereas the concomitant androgenic activity of Anavar is considered to be negligible. In addition, oxandrolone did not show any estrogenic or progestogenic activity.
Clearly, the described properties of Anavar make it very attractive for sports and bodybuilding. However, when fluid retention is undesirable, you can achieve better results in the mass formation and strength building phases. This steroid is also used when you need to reduce body fat while maintaining muscle mass if possible despite calorie restriction. Accumulation of fluids and oils should be avoided at this stage. As shown above, Anavar can be considered a universal medicine. In the comparative description of anabolic steroids, it is often referred to as a “mild” agent, although in fact it has a rather impressive anabolic effect. This is confirmed by the value of the index 322-630, which is significantly higher than the indices of Testosterone (100) and another widely used anabolic Primobolan (88). Therefore, when we talk about Anavar, the term “mild” may not mean its anabolic effects, as many people think. This is because of the oral dosage form of Anavar, as much of the anabolic steroid can be metabolised by the liver when taken orally. In this respect, the structure of oral steroids changes due to methylation at position 17, which allows to increase the resistance to destruction in the liver. This change, while not completely reversing metabolic processes, significantly increases the rate at which the drug enters the bloodstream. Some medications are still missing, which explains why the range of meanings for some steroids (mostly oral medications, which have anabolic effects that vary with liver metabolism) is presented rather than accurate.
Side Effects of Anavar
Anavar (Oxandrolone) – An Overview of Oral Steroids and Side Effects
It has already been mentioned that Anavar is very popular in medical, bodybuilding and sporting settings due to its excellent risk-benefit ratio and almost complete absence of side effects compared to most anabolic steroids.
No estrogenic effects have been observed with either Anavar or the original DHT compound. DHT is an androgenic hormone that cannot be converted into estrogen and its derivative Anavar has the same properties. In this regard, its use does not cause fluid retention, swelling, fat accumulation and gynecomastia. Also, Anavar showed no progestin activity and therefore no related adverse events.
Although the androgenic effect of Anavar is much less pronounced than testosterone, it is still possible, especially in the presence of hypersensitivity. These side effects include oily skin, acne, body hair, increased risk of male pattern baldness, and prostate adenoma.
Despite claims that Anavar is mild to the endocrine system, studies have shown mixed results. In healthy subjects, a daily dose of 15mg has been shown to impair testicular function and reduce testosterone production by approximately 40%. Anavar should not be taken lightly as it can cause severe hormonal imbalances. If a short course of the drug at a dose of 15 mg per day can inhibit the activity of the HHGO (hypothalamic-pituitary-gonadal axis), then the use of high doses, typical of bodybuilders, for several weeks can be completely constipated. axis work.
Anavar course application
Although Anavar is commonly used to dry and shape muscles, it also has other uses. Despite the fact that the drug helps to burn fat and improve physical fitness, it is also a great way to increase mass and strength, increase muscle volume. Because Anavar has several times the anabolic activity of testosterone, it can be easily used during a pattern to increase muscle mass.
However, because Anavar can affect the liver, the duration of use should be shorter than with injectable anabolic steroids. Therefore, it is usually used at the beginning of the course for the first 6-8 weeks, then discontinued. The maximum duration of the course is 10 weeks, depending on the appropriate doses. In combination with other active substances, testosterone esters (enanthate or other) and deca-durabolin (nandrolone decanoate) are used to increase muscle volume.
Shorter courses of Anavar are recommended for cutting and “drying” and are recommended for the same purpose. These drugs include testosterone propionate, Masteron, trenbolone acetate, and others. Like Anavar, these compounds do not cause unwanted visible fluid retention or bloating during the drying and cutting phases.
Anavar is an anabolic steroid that can be used by women who are athletic or bodybuilding and who are trying to avoid masculinity. Anavar is recommended for bodybuilding and sports purposes for up to 4-6 weeks in both men and women.